8 Top Healthcare Venture Capital Firms

The intersection of healthcare and technology has created unprecedented opportunities for innovation, driving venture capital (VC) firms to increase their investments in healthcare startups dramatically. For entrepreneurs seeking to transform healthcare through technology, understanding the landscape of specialized healthcare venture capital firms is crucial. These firms offer not only funding, but also invaluable industry expertise and connections that can help startups navigate the complex healthcare sector.

While there are numerous venture capital firms investing in healthcare globally, this overview focuses on the top healthcare venture capital firms that have demonstrated consistent commitment to healthcare innovation and technological advancement in the industry.

VCs Investing in Healthcare Companies

The healthcare sector presents unique opportunities for venture capital investment, combining traditional medical expertise with emerging technologies. Today’s healthcare VCs aren’t just providing capital — they’re actively shaping the future of healthcare delivery through strategic investments in digital health, biotech, and innovative care models. The firms highlighted below exemplify this approach, each bringing their own expertise and investment focus to the healthcare ecosystem.

Disclaimer: With so many venture capital firms around the world, we aren’t able to cover them all. Furthermore, the following VC firms aren’t officially ranked and are listed in no particular order.

1. New Enterprise Associates (NEA)

• Location: San Francisco, California
• Notable Portfolio Companies: Bright Health Group, Adaptimmune, Inventiva 

New Enterprise Associates (NEA) is a well-known venture capital firm that has established itself as a powerhouse in both the healthcare and technology investment sectors. The firm frequently gives seed funding and Series A+ funding to companies it believes are making an impact in their industry. Founders who end up receiving funding and working with NEA also will benefit from NEA’s extensive mentorship opportunities, expert guidance, and industry experience and connections. 

2. Kleiner Perkins

• Location: San Francisco, California
• Notable Portfolio Companies: Flexus Biosciences, Viz.ai, Modern Health

Kleiner Perkins is a venture capital firm that’s known as one of the most prominent investors in the Menlo Park/San Francisco Bay Area. The firm has shaped the technology and healthcare landscape by backing industry giants like Google, Amazon, and Spotify. The firm’s healthcare investment strategy focuses on transformative companies in life sciences and digital health, providing both early stage funding and the expertise startups need to scale successfully in the healthcare sector.

3. SV Health Investors

• Location: Boston, Massachusetts
• Notable Portfolio Companies: Bicycle, Nordic Consulting Partners, Nimbus Therapeutics 

SV Health Investors is a venture capital firm that, as the name suggests, works primarily with companies in the healthcare industry. The firm invests in companies focused on healthcare growth, biotechnology, medical technology, dementia, and even public equities. The firm’s goal is to transform healthcare one investment at a time and support innovative entrepreneurs and founders who build groundbreaking treatments and companies within the healthcare sector. 

4. OrbiMed 

• Location: New York, New York
• Notable Portfolio Companies: SpringWorks Therapeutics, Avita Medical, MinervaX

As one of the world’s largest dedicated healthcare investment firms, OrbiMed manages approximately $17 billion in assets under management. This firm’s reach extends from early stage private companies to large multinational corporations with investments spanning therapeutics, diagnostics, medical devices, and healthcare services.

5. ARCH Venture Partners

• Location: Chicago, Illinois
• Notable Portfolio Companies: Juno Therapeutics, Boundless Bio, Illumina

ARCH Venture Partners has established itself as a pioneer in healthcare venture capital — particularly in the biotech sector. The firm distinguishes itself through a unique approach that combines company creation with traditional venture investment. The ARCH team works closely with scientific founders to transform groundbreaking research in areas like cell therapy, gene editing, and synthetic biology into viable commercial enterprises. This hands-on approach to company-building has resulted in numerous successful ventures that have fundamentally changed the landscape of modern medicine.

6. Venrock

• Location: Palo Alto, California 
• Notable Portfolio Companies: Corvidia, Nest, Anacor 

Venrock’s healthcare investment practice builds on the pioneering spirit of the Rockefeller family, combining deep scientific understanding with commercial insight. The firm has consistently identified and supported companies developing breakthrough therapeutic platforms and revolutionary medical devices. Venrock’s approach emphasizes both technological innovation and market transformation, seeking companies that can fundamentally improve healthcare delivery and patient outcomes.

7. General Catalyst 

• Location: Cambridge, Massachusetts 
• Notable Portfolio Companies: Commure, Maven, Cityblock Health 

General Catalyst has emerged as a leading force in digital health transformation, bringing its technology expertise to healthcare innovation. The firm’s healthcare portfolio reflects a deep understanding of how technology can address healthcare’s most pressing challenges. General Catalyst combines capital with extensive operational support, helping portfolio companies navigate the complex intersection of healthcare and technology. 

8. 5AM Ventures 

• Location: San Francisco, California
• Notable Portfolio Companies: Ensoma, Flexion, Pearl

5AM Ventures, aptly named for the early stage at which the firm begins working with companies, has established itself as a cornerstone investor in life sciences innovation. The firm specializes in building companies from inception through early clinical development with a particular focus on breakthrough discoveries in areas like precision medicine, biological engineering, and novel therapeutic platforms. 5AM Ventures’ hands-on approach involves active collaboration with scientific founders — often working alongside them in portfolio companies’ laboratories during the crucial early stages of development.